research Smart Responsive Microneedles for Controlled Drug Delivery
Smart microneedles can deliver drugs painlessly and accurately for diseases like diabetes and tumors.
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research Inhibitory Effects of Polyacetylene Compounds from Panax ginseng on Neurotrophin Receptor-Mediated Hair Growth
Certain compounds from Panax ginseng can block proteins that affect hair growth, potentially helping treat hair loss.
research Thiohydrazides in the Synthesis of Functionalized Extranuclear Heterosteroids
New steroid derivatives show promise as anticancer agents, even against resistant cells.
research Influence of the alkylsulfonylamino substituent located at the 6-position of 2,2-dimethylchromans structurally related to cromakalim: From potassium channel openers to calcium entry blockers?
New compounds similar to cromakalim were less effective at inhibiting insulin release but improved in solubility and one acted as a calcium entry blocker, not a potassium channel opener.
research A bioactive, multifunctional hydrogel dressing from sugarcane molasses extract promotes scarless healing in chronic wounds via microenvironment-responsive drug release
research Penggunaan Simplex Lattice Design (SLD) dalam Optimasi HPMC dan Propilen Glikol Formula Gel Cinchonine Sebagai antibakteri Cutibacterium acnes (C.Acne)
The optimized Cinchonine gel effectively fights acne bacteria and is safe for twice-daily use.
research Novel Synthetic Steroid Derivatives: Target Prediction and Biological Evaluation of Antiandrogenic Activity
New steroid compounds may help with hormonal therapy and have potential benefits for glucose disorders, but more research is needed.
research Understanding the formation mechanism of drug-polymer inclusion complex by structure elucidation and theoretical calculation
The research shows how certain drug molecules form stable structures with polymers, which could help create new drug forms.
research Facile General Injectable Gelatin/Metal/Tea Polyphenol Double Nanonetworks Remodel Wound Microenvironment and Accelerate Healing
New injectable hydrogels with gelatin, metal, and tea polyphenols help heal diabetic wounds faster by controlling infection, improving blood vessel growth, and managing oxidative stress.
research Mitigating GLP-1–Related Dermatologic Adverse Effects through Methylene Blue’s Antioxidant Action
Methylene blue, combined with ceramides, may reduce skin and hair side effects from GLP-1 therapy.
research PIK3CA gain-of-function mutation in Schwann cells leads to severe neuropathy and aerobic glycolysis through a non-cell autonomous effect
A PIK3CA mutation in Schwann cells causes severe nerve damage and increased glycolysis, but early treatment can help.
research The Emerging Structural Pharmacology of ATP-Sensitive Potassium Channels
KATP channels are important for energy balance and are targeted by drugs for diabetes, hypoglycemia, hypertension, and hair loss.
research Low fucosylation defines the glycocalyx of progenitor cells and melanocytes in the human limbal stem cell niche
Low fucosylation boosts stem cell growth in the eye.
research The development of a solid lipid nanoparticle (SLN)-based lacticin 3147 hydrogel for the treatment of wound infections
The new gel effectively treats MRSA-infected wounds for longer.
research Interpenetrating gelatin/sodium alginate hydrogel with controlled PRP lysate delivery for accelerating diabetic wound healing with reduced scarring
The hydrogel speeds up diabetic wound healing and reduces scarring.
research Screening of drugs with potential antifungal activity for repurposing in the treatment of cryptococcosis.
Certain antiparasitics and antidepressants show promise for treating cryptococcosis, especially when combined with fluconazole.
research pH sensitive nano layered double hydroxides reduce the hematotoxicity and enhance the anticancer efficacy of etoposide on non-small cell lung cancer
The nano-carrier makes etoposide safer and more effective against lung cancer.
research Circumventing Mukaiyama oxidation: selective S–O bond formation via sulfenamide–alcohol coupling
A new, efficient method creates sulfinimidate esters from sulfenamides and alcohols without metals.
research A functional study of a case of glucagonoma exhibiting typical glucagonoma syndrome
A pancreatic tumor caused high glucagon levels and symptoms, but treatment reduced glucagon and shrank liver tumors.
research N-Acyl arylsulfonamides as novel, reversible inhibitors of human steroid sulfatase
Scientists found new, better-working inhibitors for a hormone-related enzyme.
research Injectable Polypeptide‐Protein Hydrogels for Promoting Infected Wound Healing
The hydrogel promotes faster healing of infected wounds by enhancing tissue regeneration and preventing infection.
research BroadAMP-GPT: AI-Driven generation of broad-spectrum antimicrobial peptides for combating multidrug-resistant ESKAPE pathogens
BroadAMP-GPT effectively creates antimicrobial peptides to fight drug-resistant bacteria.
research Comparison differentiated osteoblast from adipose stem cells and normal osteoblast
Glycoconjugates help heal hair follicles during skin repair.
research Metabolic complications of glucocorticoids – Prevention by metformin
Metformin can help prevent the side effects of glucocorticoid medications on metabolism.
research Formulation, Development and Evaluation of Ciclopirox Olamine Nanogel for the Treatment of Cutaneous Candidiasis
The nanogel with Ciclopirox Olamine is a promising treatment for skin yeast infections.
research Acute Hepatitis and Pancytopenia in a Child With Chronic Abuse of Senna
A child's chronic use of Senna caused liver damage and a severe decrease in blood cells, but improved after stopping Senna and getting treatment.
research Emulgel: A Novel Approach For Hydrophobic Drugs
Emulgels effectively deliver hydrophobic drugs for skin conditions like acne and psoriasis.
research Research advances in smart responsive-hydrogel dressings with potential clinical diabetic wound healing properties
Smart hydrogel dressings could improve diabetic wound healing by adjusting to wound conditions and controlling drug release.
research Fiber-reinforced hydrogel dressings for enhanced herbal compounds delivery in accelerated diabetic wound healing
The MeGel-SFSR dressing helps diabetic wounds heal faster and better.
research Catechol-chitosan/polyacrylamide hydrogel wound dressing for regulating local inflammation
The hydrogel dressing effectively treats chronic wounds by regulating inflammation and improving healing.