March 2024 in “Indian Journal of Dermatology” The man was diagnosed with Cronkhite-Canada syndrome, a rare disorder with GI polyps, skin issues, hair loss, and nail problems.
September 2023 in “Journal of the American Academy of Dermatology” The cosmetic product improved melasma and skin quality without causing irritation.
August 2023 in “Gastroenterology” A 78-year-old man with Cronkhite-Canada syndrome improved significantly after treatment and remains symptom-free.
January 2023 in “The Egyptian Journal of Hospital Medicine” Platelet-Rich Plasma (PRP) is a promising new treatment for skin strain scars, with no risk of dark spots or infection.
September 2021 in “CRC Press eBooks” Pregnancy can cause normal skin changes, including darkening of certain areas, nail changes, vascular changes, and breast changes like stretch marks.
October 2017 in “The American Journal of Gastroenterology” Early diagnosis and nutritional support are crucial for managing Cronkhite-Canada Syndrome.
November 2015 in “Clin-Alert” Some medications and supplements can cause serious side effects, including hair loss, heart rhythm problems, liver injury, and other health issues.
4 citations
,
July 2019 in “Clinics in Dermatology” The document concludes that while white skin, nail, and mucosa diseases increase skin cancer risk, they are generally harmless, especially compared to darker pigmentation conditions.
November 2021 in “CRC Press eBooks” Hair color is determined by melanin and can be affected by genetic conditions like albinism.
2 citations
,
March 2005 in “Journal of the American Academy of Dermatology” Wigs are still a popular solution for hair loss to maintain a youthful look.
10 citations
,
September 1994 in “International Journal of Dermatology” Three Iranian men had reddish-brown facial pigmentation with no effective treatment.
7 citations
,
January 2008 in “Indian Journal of Dermatology” Pigmentary mosaicism causes skin color changes and can affect multiple body systems, but has no cure.
October 2019 in “International journal of research in dermatology” Misusing topical corticosteroids can cause skin darkening and other side effects.
October 2019 in “European Journal of Dermatology” The boy's hair and skin color differences are due to a pigmentation disorder.
56 citations
,
December 1978 in “The Journal of Dermatologic Surgery and Oncology” Transplanting small skin grafts can successfully repigment leukoderma.
4 citations
,
February 2014 in “Journal of the European Academy of Dermatology and Venereology” Early diagnosis of hair tourniquet syndrome saved a baby's toe from being lost.
April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology” The model can effectively test gene functions and drug responses in human skin.
PmtHEE is a better model for studying pigmented skin because it includes melanocytes and shows improved cell differentiation.
March 2026 in “European Journal of Biomedical and Life Sciences” Restorative dermopigmentation improves skin appearance and function by addressing specific skin issues.
84 citations
,
April 2005 in “Dermatologic Clinics” Treatments for melanin disorders exist, but more effective options needed.
2 citations
,
January 2002 in “Clinics in Dermatology” Vitiligo causes white skin patches, often starts before age 20, and is linked to other health issues.
January 2023 in “Indian Dermatology Online Journal” Micropigmentation is a cosmetic tattooing technique for hiding skin issues and creating permanent makeup, but it can have side effects.
15 citations
,
December 2016 in “Obstetrics & Gynecology” Most skin changes during pregnancy are harmless and moles don't significantly change, but many women experience pigmentation changes due to hormones and sun exposure.
September 2018 in “CRC Press eBooks” Hair and nail disorders can cause changes in scalp pigmentation, especially with sun exposure and alopecia.
January 1990 in “Springer eBooks” Some chemicals can permanently or temporarily remove color from skin and hair, which can be distressing and is not well-regulated in cosmetics.
35 citations
,
July 2007 in “Dermatologic clinics” Facial dark spots can be caused by the sun, genetics, makeup, or medicine, and are diagnosed by patient history and skin tests.
37 citations
,
October 2017 in “Advanced drug delivery reviews” The review suggests that there are various treatments to help restore skin color after severe burns.
13 citations
,
January 2009 in “The Open Dermatology Journal” Oral pigmentation can be a sign of Addison's disease.
Skin diseases look different on pigmented and nonpigmented skin.
November 2025 in “International Journal of Advanced Research” Platelet-rich plasma therapy effectively treated laser-induced skin lightening.