305 citations
,
March 2018 in “International journal of molecular sciences” The document concludes that the understanding of scar formation is incomplete and current prevention and treatment for hypertrophic scars and keloids are not fully effective.
47 citations
,
November 2012 in “Wound repair and regeneration” Nude mice with grafted human skin developed scars similar to human hypertrophic scars.
45 citations
,
January 2021 in “Stem Cell Research & Therapy” The combination of stem cell medium and hydrogel effectively reduces and improves hypertrophic scars.
35 citations
,
October 2014 in “Wound Repair and Regeneration” The model helps understand scar contraction and develop new treatments.
32 citations
,
December 2015 in “PloS one” P144® improves hypertrophic scars by reducing size and thickness and increasing elasticity.
21 citations
,
December 2023 in “Bioengineering & Translational Medicine” Fibroblast and endothelial cell interactions are crucial in forming hypertrophic scars.
18 citations
,
November 2009 in “Archives of Dermatology” Calcipotriol doesn't prevent hypertrophic scars, but keratinocyte activation is important in scar formation.
13 citations
,
January 2022 in “Stem cell reviews and reports” Mouse stem cells from hair follicles can improve wound healing and reduce scarring.
10 citations
,
January 2015 in “European journal of pharmacology” Ginsenoside Rb1 may help remodel hypertrophic scars effectively at a dose of 0.56 mg.
9 citations
,
November 2015 in “Plastic and reconstructive surgery/PSEF CD journals” Gene knockout mice developed scars similar to human hypertrophic scars, useful for studying scar progression.
5 citations
,
September 2023 in “Journal of Cosmetic Dermatology” c-Maf positive macrophages help form hypertrophic scars by affecting fibroblasts and collagen production.
5 citations
,
November 2011 in “Journal of Cutaneous Medicine and Surgery” Hairless dogs can be used to study human hypertrophic scars.
2 citations
,
November 2014 in “International Scholarly Research Notices” The terpenoid fraction may cause thicker scars by delaying wound healing.
1 citations
,
May 2010 in “Chinese journal of plastic surgery” Melatonin might help treat thick scars.
July 2025 in “Burns & Trauma” 3D cell spheroids can help reduce scars by delivering therapeutic vesicles.
January 2025 in “Open Medicine” High-concentration cell-free adipose extract reduces scar formation and improves scar appearance.
July 2024 in “Research Square (Research Square)” Certain proteins can either protect against or increase the risk of hypertrophic scars.
January 2005 in “中华医学杂志:英文版” Scar tissue may regenerate sweat glands from remaining glands or stem cells.
October 2025 in “Dermatology Practical & Conceptual” Dermatoscopy helps track scar changes and guide treatment.
October 2025 in “Journal of Cosmetic Dermatology” Botulinum toxin Type A helps reduce hypertrophic scars and is generally safe.
October 2025 in “International Wound Journal” Gamma-irradiated amniotic fluid improves healing and reduces thickness of hypertrophic scars.
July 2025 in “Interdisciplinary materials” A microneedle patch with curcumin and stem cell components effectively treats hypertrophic scars and promotes healing.
1 citations
,
March 2023 in “Pharmaceutics” PBMCsec can help reduce and improve thick skin scars.
April 2024 in “International journal of molecular sciences” Combination pharmacotherapy is generally more effective for treating keloids and hypertrophic scars.
36 citations
,
February 2016 in “British journal of pharmacology” Sirtuin 1 could be a potential drug target for treating hypertrophic scars.
176 citations
,
June 2019 in “Cells” Different fibroblasts play key roles in skin healing and scarring.
113 citations
,
June 2019 in “F1000Research” Scarless healing is complex and influenced by genetics and environment, while better understanding could improve scar treatment.
81 citations
,
January 2000 in “American journal of clinical dermatology” Various treatments can improve post-acne scars, but results vary.
13 citations
,
June 2012 in “Dermatologic Surgery” Severe scars need a mix of treatments for best results.
10 citations
,
January 2018 in “Elsevier eBooks” Burn scars heal abnormally and more research is needed to find better treatments.