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GlossaryMonocyte Chemoattractant Protein-1

signaling protein that attracts monocytes to inflammation sites

Monocyte Chemoattractant Protein-1 (MCP-1), also known as CCL2, is a signaling protein that plays a crucial role in the immune system by attracting monocytes, a type of white blood cell, to sites of inflammation or injury. This protein is important in the body's response to infection and tissue damage, but excessive MCP-1 activity can contribute to chronic inflammatory diseases.

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Oral Contraceptive Pill Treatment Alters Gene Expression of Inflammatory Markers in Polycystic Ovary Syndrome Women

research Oral contraceptive pill (OCP) treatment alters the gene expression of intercellular adhesion molecule-1 (ICAM-1), tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1 (MCP-1) and plasminogen activator inhibitor-1 (PAI-1) in polycystic ovary syndrome (PCOS) women compared to drug-naive PCOS women

2 citations , February 2023 in “BMC women's health”

Birth control pills change the activity of certain inflammation and blood clotting genes in women with PCOS.

research C‐reactive protein promotes adhesion of monocytes to endothelial cells via NADPH oxidase‐mediated oxidative stress

24 citations , January 2012 in “Journal of Cellular Biochemistry”

C-reactive protein helps monocytes stick to blood vessel cells by causing oxidative stress.

research LL-37 stimulates the functions of adipose-derived stromal/stem cells via early growth response 1 and the MAPK pathway

53 citations , April 2016 in “Stem cell research & therapy”

LL-37 helps stem cells grow and move, aiding tissue regeneration and hair growth.

research Different levels of EGF, VEGF, IL‐6, MCP‐1, MCP‐3, IP‐10, Eotaxin and MIP‐1α in the adipose‐derived stem cell secretome in androgenetic alopecia

1 citations , February 2022 in “Experimental Dermatology”

Certain proteins are found at higher levels in balding areas compared to non-balding areas, suggesting a link to hair loss. This could be useful for diagnosing and treating hair loss.

research Different Levels of EGF, VEGF, IL-6, MCP-1, MCP-3, IP-10, Eotaxin and MIP-1𝛼 in Adipose Derived Stem Cells (ADSCs) Secretome in Androgenetic Alopecia

January 2021

Higher levels of certain proteins in hair loss areas may help understand and treat hair loss.

research Accelerative action of topical piperonylic acid on mice full thickness wound by modulating inflammation and collagen deposition

3 citations , October 2021 in “PLoS ONE”

Piperonylic acid speeds up wound healing by reducing inflammation and boosting collagen.

Cardiac and Brainstem Neuroinflammatory Pathways Account for Androgenic Incitement of Cardiovascular and Autonomic Manifestations in Endotoxic Male Rats

research Cardiac and brainstem neuroinflammatory pathways account for androgenic incitement of cardiovascular and autonomic manifestations in endotoxic male rats

1 citations , April 2021 in “Journal of Cardiovascular Pharmacology”

Testosterone plays a big role in heart and nervous system damage caused by inflammation in male rats, suggesting that blocking testosterone production could help manage this condition.

Rat Hair Follicle Stem Cell-Derived Exosomes: Isolation, Characterization, and Comparative Analysis of Their In Vitro Wound Healing Potential

research Rat Hair Follicle Stem Cell-Derived Exosomes: Isolation, Characterization and Comparative Analysis of Their In Vitro Wound Healing Potential

May 2025 in “International Journal of Molecular Sciences”

Exosomes from rat hair follicle stem cells may help heal wounds and regenerate skin.

research FC053 Pro-inflammatory cytokine cascade in human plucked hair

September 1997 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

Anti-IL-1 treatments might help with certain types of hair loss in people with high inflammation.

research Exploring the Impact of Systemic Inflammatory Regulators on Rosacea Risk: A Bidirectional Mendelian Randomization Analysis

1 citations , January 2025 in “Clinical Cosmetic and Investigational Dermatology”

Higher levels of certain proteins may increase or decrease rosacea risk.

research Assessment of chemokines MIP-1α and MIP-1 βin Iraqi women with polycystic ovarian syndrome

1 citations , October 2023 in “Egyptian Journal of Immunology”

PCOS is linked to low-grade chronic inflammation.

Platelet-Derived Growth Factor Regulates the Proliferation and Differentiation of Human Melanocytes in a Differentiation-Stage-Specific Manner

research Platelet-derived growth factor regulates the proliferation and differentiation of human melanocytes in a differentiation-stage-specific manner

10 citations , May 2016 in “Journal of Dermatological Science”

PDGF-BB helps young melanocytes grow but stops mature ones from growing, and it makes melanocytes more specialized.

Transforming Growth Factor-Beta in Stem Cells and Tissue Homeostasis

research Transforming growth factor-β in stem cells and tissue homeostasis

245 citations , January 2018 in “Bone Research”

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

research Effects of a complex mixture prepared from agrimonia, houttuynia, licorice, peony, and phellodendron on human skin cells

4 citations , December 2020 in “Scientific Reports”

The plant extract mixture improves skin health by reducing inflammation, boosting collagen, and supporting anti-aging.

research 17β-estradiol Inhibits the Production of RANTES in Human Keratinocytes

56 citations , March 2003 in “Journal of Investigative Dermatology”

17β-estradiol can reduce inflammation in the skin.

research Proteomic analysis of human mesenchymal stromal cell secretomes: a systematic comparison of the angiogenic potential

187 citations , April 2019 in “npj Regenerative Medicine”

Wharton's jelly secretomes are best for promoting blood vessel growth.

research NOVEL CORONAVIRUS (SARS-COV-2): MOLECULAR BIOLOGY, PATHOGENESIS, PATHOBIOLOGY AND ADVANCES IN TREATMENT OF COVID-19 PATIENTS– AN UPDATE

1 citations , December 2020 in “Journal of Experimental Biology and Agricultural Sciences”

COVID-19 is caused by a virus from bats, and efforts focus on prevention and treatment research.

research Role of Dermal Factors Involved in Regulating the Melanin and Melanogenesis of Mammalian Melanocytes in Normal and Abnormal Skin

April 2024 in “International journal of molecular sciences”

Dermal factors are crucial in regulating melanin production in skin.

The Regulatory Role of the Tetrapeptide AcSDKP in Skin and Hair Physiology and the Prevention of Aging Effects in These Tissues – A Potential Cosmetic Role

research The regulatory role of the tetrapeptide AcSDKP in skin and hair physiology and the prevention of ageing effects in these tissues – a potential cosmetic role

13 citations , March 2013 in “International Journal of Cosmetic Science”

AcSDKP may help prevent skin and hair aging and promote their growth.

research The Effect of the Aqueous Extract of Bidens Pilosa L. on Androgen Deficiency Dry Eye in Rats

27 citations , January 2016 in “Cellular Physiology and Biochemistry”

Bidens pilosa L. extract effectively treats androgen deficiency dry eye in rats.

research Biomaterials Functionalized with MSC Secreted Extracellular Vesicles and Soluble Factors for Tissue Regeneration

220 citations , March 2020 in “Advanced functional materials”

Biomaterials with MSC-derived substances could improve tissue repair and have advantages over direct cell therapy.

research Conditional knock out of N-WASP in keratinocytes causes skin barrier defects and atopic dermatitis-like inflammation

27 citations , July 2017 in “Scientific Reports”

N-WASP is essential for healthy skin and preventing inflammation.

research Olink proteomics analysis of scalp psoriasis reveals a cytokine storm inflammatory mainly related to bacterial-derived antigens

July 2025

Scalp psoriasis inflammation is mainly caused by bacteria-related triggers.

research Impact of Cernitin™ on induced chronic prostatitis in animal model for understanding management of lower urinary tract symptoms

1 citations , March 2021 in “Phytomedicine plus”

Cernitin™, a pollen extract, was found to significantly reduce pain and inflammation in rats with chronic prostatitis, suggesting it could be a useful alternative to certain anti-inflammatory drugs.

research Deep skin fibroblast-mediated macrophage recruitment supports acute wound healing

3 citations , August 2024

Deep skin fibroblasts help recruit immune cells for better wound healing.

research Abstracts

October 2020 in “Veterinary Dermatology”

New treatments and diagnostic methods for various animal skin conditions showed promising results.

research Increased CRHR1 expression on monocytes from patients with AA enables a pro‐inflammatory response to corticotrophin‐releasing hormone

3 citations , October 2024 in “Experimental Dermatology”

Higher CRHR1 levels in AA patients lead to increased inflammation.

research The Immune Functions of Keratinocytes in Skin Wound Healing

147 citations , November 2020 in “International Journal of Molecular Sciences”

Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.

research GPCRs as key regulators in wound healing

April 2026 in “Frontiers in Cell and Developmental Biology”

GPCRs are vital for wound healing by affecting cell growth and immune response.

research Mammalian Fetal Organ Regeneration

32 citations , January 2005 in “Advances in Biochemical Engineering / Biotechnology”

Fetal wounds heal without scarring because of different biological factors, which could help improve adult wound healing.