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ODC expression in mouse skin and tumors is varied and can be inhibited by retinoic acid or cycloheximide.

Inhibiting ODC can prevent UV-induced skin cancer.

OXI1 kinase is essential for plant defense and root hair growth in Arabidopsis.

Orai1 protein is crucial for tooth development and affects enamel thickness and mineralization.

A new compound effectively inhibits human 5α-reductase 1.

Inhibitors of 11β-HSD1 show potential for treating type 2 diabetes but require more testing for safety and effectiveness.

Scientists made a carbon-14 labeled version of a drug with a 48% yield and over 99% purity.

TPA strongly increases ODC activity in certain skin cells, potentially aiding tumor growth.

D'orenone stops root hair growth by disrupting auxin transport, but adding auxin can reverse this.

Targeting ornithine decarboxylase can help prevent skin cancer.

PH-762 shows promise in treating skin cancer by effectively targeting and silencing PD-1 in tumors with minimal side effects.

The nature of the side chain in RU 58841 derivatives greatly affects its AR affinity, with the N-(iodopropenyl) derivative 13 showing the highest AR binding affinity, suggesting its potential for developing high-affinity radioiodinated AR radioligands.

A new genetic mutation in the ODC1 gene causes developmental delay and other symptoms in a young girl.

Near-infrared probes can safely and effectively image cysteine protease activity for disease diagnosis.

ODC1 gene mutations cause a neurodevelopmental disorder with large head size, hair loss, and facial abnormalities.

Inhibiting ornithine decarboxylase may help prevent certain skin cancers.

INT effectively shows enzyme activity and protein groups in wool and hair follicles.

FP-1 is a key protein in rat hair growth, active only during the growth phase.

The new device improves surgical accuracy by using a special dye and camera to see inside tissues.

Different PADI isoforms help cells develop diverse functions.

The OVOL1-OVOL2 axis is important for hair follicle differentiation and can help diagnose certain hair-related tumors.

New steroidal compounds moderately block an enzyme related to testosterone conversion, less effectively than finasteride.

The document confirms the structures of major metabolites of the CRTh2 antagonist Setipiprant and identifies minor metabolites.

K6/ODC transgenic mice are effective for quickly identifying cancer-causing chemicals.

Optimizing the structure of a specific compound greatly improved its effectiveness and precision for treating diabetic complications.