305 citations
,
March 2018 in “International journal of molecular sciences” The document concludes that the understanding of scar formation is incomplete and current prevention and treatment for hypertrophic scars and keloids are not fully effective.
142 citations
,
September 2015 in “PubMed” Keloid scars are aggressive, excessive skin scars with unique features and complex diagnosis.
56 citations
,
January 2022 in “Burns & Trauma” WNT5A contributes to keloid scars by promoting cell changes through specific signaling pathways.
46 citations
,
July 2015 in “Wound repair and regeneration” Keloid scars may form due to changes in skin cell characteristics and specific protein signaling.
40 citations
,
May 2010 in “American Journal of Clinical Dermatology” AKN might be a skin marker for metabolic syndrome.
35 citations
,
July 2018 in “BMJ Open” People with atopic dermatitis have a higher risk of developing keloids, especially women, those under 40, and those with severe symptoms.
35 citations
,
January 2008 in “American Journal of Clinical Dermatology” KFSD can be linked to acne keloidalis nuchae and tufted hair folliculitis.
31 citations
,
March 2016 in “Journal of Investigative Dermatology” AKR1B10 enzyme may cause keloid scars and could be a treatment target.
21 citations
,
February 2015 in “Clinical Cosmetic and Investigational Dermatology” Keloids may be influenced by stress and psychological factors.
19 citations
,
October 2017 in “Dermatologic Surgery” The alexandrite laser is a safe and effective treatment for Acne Keloidalis Nuchae.
17 citations
,
January 2024 in “Burns & Trauma” miR-26b-5p in macrophage exosomes helps keloids grow.
11 citations
,
July 2022 in “Frontiers in Immunology” Four specific genes are linked to keloid formation and could be potential treatment targets.
10 citations
,
December 2011 in “PubMed” Methotrexate effectively managed SAPHO syndrome symptoms when other treatments failed.
9 citations
,
November 2022 in “Journal of Cosmetic Dermatology” Combining cryotherapy with steroids reduces keloid size more effectively than steroids alone.
8 citations
,
March 2023 in “International Wound Journal” IGF2BP3 and other m6A-related genes are linked to keloid formation and could be potential treatment targets.
7 citations
,
January 2017 in “International Journal of Trichology” Hair transplant can cause hard-to-treat keloids in some patients.
6 citations
,
October 2024 in “International Journal of Dermatology” Proinflammatory fibroblasts and vascular endothelial cells are key in keloid development.
5 citations
,
April 2021 in “International Journal of Homoeopathic Sciences” Homeopathy improved Acne Keloidalis Nuchae in a 14-year-old.
4 citations
,
January 2020 in “Journal of Cutaneous and Aesthetic Surgery” Keloid scars can form after hair transplant surgery and should be prevented and treated early.
3 citations
,
February 2024 in “Wound Repair and Regeneration” Keloids on the penis are rare, often triggered by circumcision, and rarely recur after surgery.
3 citations
,
August 2023 in “Clinical Cosmetic and Investigational Dermatology” Keloids can form at the site of a healed herpes zoster infection, but the reason is unclear.
3 citations
,
August 2019 in “JAAD Case Reports” Temporary hair loss can occur after 5-fluorouracil treatment for keloids.
3 citations
,
January 2010 in “PubMed” We lack effective keloid treatments because their causes are not well understood.
2 citations
,
August 2022 in “Emergency medicine international” Keloid skin disorder involves abnormal fibroblast activation and immune response, linked to a group of genes including FGF11.
1 citations
,
November 2024 in “Journal of Cosmetic Dermatology” It's generally safe to have most skin procedures after isotretinoin, but avoid aggressive treatments and use a lower dose.
1 citations
,
January 2025 in “Burns & Trauma” Targeting Midkine can help reduce pain and itching in keloids.
May 2026 in “Nature Communications” Targeting catecholaminergic signaling may help treat keloid scars.
July 2024 in “Journal of Investigative Dermatology” Spontaneous keloids may be linked to nephrogenic systemic fibrosis in dialysis patients.
January 2023 in “Research Square (Research Square)” IGF2BP3 gene is up-regulated in keloid patients, suggesting potential targets for treatment.
Low-dose radiation and certain drugs can inhibit keloid growth, revealing potential treatment targets.