December 2025 in “Frontiers in Immunology” Restoring nerve-macrophage communication may help treat autoimmune diseases.
September 2024 in “Journal of the American Academy of Dermatology” Seborrheic dermatitis affects quality of life and sleep, linked to stress and nervous system changes.
50 citations
,
April 2021 in “Frontiers in Immunology” New therapies targeting skin neuroimmune interactions could treat neuropathic pain.
12 citations
,
November 2024 in “Burns & Trauma” Neuroregulation is crucial for skin wound healing and can be targeted to improve recovery.
August 2006 in “Experimental dermatology” Neurotrophins are important for hair growth and response to stress.
Understanding hair follicle signaling can improve hair disorder treatments.
1 citations
,
December 2025 in “Scientific Reports” A machine learning model can predict alopecia areata early using specific gene markers.
2 citations
,
February 2021 in “Brain Research” Testosterone affects blood pressure control and inflammation in male rats with endotoxic shock, and blocking certain hormones may help treat it.
September 2025 in “Cureus” GLP-1 agonists may help treat certain skin conditions.
127 citations
,
December 2005 in “Experimental Dermatology” Stress can stop hair growth in mice, and treatments can reverse this effect.
Rosacea may be linked to gut and brain issues, not just a skin problem.
48 citations
,
January 2000 in “Hormone Research in Paediatrics” Cytokines and neuropeptides are key in controlling androgen levels, affecting skin and hair conditions.
February 2026 in “Medicina” Hyaluronic Acid Profhilo® reduces skin inflammation and nerve-related pain in atopic dermatitis.
228 citations
,
January 2021 in “Journal of Neuroimmune Pharmacology” Men have more severe COVID-19 outcomes than women.
115 citations
,
November 2004 in “Brain Behavior and Immunity” Stress increases nerve fibers and immune cell activity in mouse skin, possibly worsening skin conditions.
5 citations
,
February 2010 in “Expert Review of Dermatology” Treating both the mind and skin together, especially by managing stress, can greatly improve outcomes for skin disorders linked to psychological issues.
January 2026 in “Journal of Biosciences and Medicines” Chronic kidney disease can cause skin issues that need early recognition and combined treatment for better outcomes.
7 citations
,
October 2023 in “European Journal of Pharmacology” Cannabidivarin (CBDV) may help brain cell growth and survival through the TRPV1 receptor.
February 2026 in “Advanced Sensor Research” Advanced technologies can improve understanding and monitoring of skin-brain interactions.
9 citations
,
May 2023 in “Stem Cell Research & Therapy” Stem cell treatment from umbilical cords reduces symptoms of atopic dermatitis and may help hair growth.
1 citations
,
September 2025 in “Physiologia” Ovalbumin–aluminum sensitization causes increased pain sensitivity and nerve changes in mice.
November 2023 in “Frontiers in Neuroendocrinology” Some people experience lasting sexual, psychological, and sleep problems after using finasteride or SSRI antidepressants, possibly due to similar underlying causes.
158 citations
,
June 2017 in “Maturitas” Estrogen helps improve skin aging and healing, especially in post-menopausal women.
March 2026 in “Frontiers in Immunology” Regulatory T cells help heal skin wounds by reducing inflammation and promoting tissue repair.
176 citations
,
January 2003 in “Journal of Investigative Dermatology” Bone Morphogenetic Proteins (BMPs) help control skin health, hair growth, and color, and could potentially be used to treat skin and hair disorders.
57 citations
,
March 2019 in “Immunity” The document concludes that the skin's immune system is complex, involving interactions with hair follicles, nerves, and microbes, and can protect or cause disease, offering targets for new treatments.
50 citations
,
May 2019 in “Drugs” Cannabinoids may help treat chronic and chemotherapy-induced neuropathic pain, but more research is needed to confirm their effectiveness and safety.
31 citations
,
March 2015 in “The Journal of Steroid Biochemistry and Molecular Biology” Neuroactive steroids could become safe, effective treatments with more understanding of their complex brain actions and metabolism.
18 citations
,
March 2020 in “Frontiers in Neuroendocrinology” The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.
February 2026 in “Frontiers in Immunology” Age-related immune changes worsen Parkinson's disease, suggesting new treatment strategies.