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This study introduces a taurine-based active pharmaceutical ingredient ionic liquid (CTIL) as a novel treatment for androgenic alopecia (AGA). CTIL is synthesized through a one-step method and functions both as a delivery carrier and a therapeutic agent. It effectively penetrates the skin barrier, targeting hair follicles to deliver antioxidants and modulate the perifollicular microenvironment by scavenging reactive oxygen species (ROS). In vitro studies show that CTIL's hydrogen-bond network structure enhances its penetration and accumulation in hair follicles. In an AGA animal model, CTIL reduced ROS, alleviated oxidative damage and inflammation, inhibited hair follicle miniaturization, and promoted hair regrowth. This research highlights the potential of bioactive ionic liquids in treating AGA by integrating delivery and therapeutic functions.

Polyendocrine Metabolic Ovarian Syndrome (PEMOS), also known as Polycystic Ovary Syndrome (PCOS), is a common disorder affecting women's reproductive health, characterized by symptoms such as hyperandrogenism and insulin resistance. Current treatments have limitations, especially in low- and middle-income countries. Parquetina nigrescens, a medicinal plant from West Africa, shows promise in managing PEMOS due to its antioxidant, anti-inflammatory, and reproductive-modulating properties. This review suggests that P. nigrescens could improve ovarian function, reduce oxidative stress, and enhance insulin sensitivity, making it a potential complementary therapy for PEMOS. The review emphasizes the need for further research into its safety and efficacy.

The study introduces a bioinspired melanoidin/tannic acid (MD/TA) nanocomplex designed to protect hair from UV radiation. This nanocomplex forms a robust, photoprotective coating on hair fibers, leveraging melanoidin's UVA absorption and tannic acid's broad-spectrum UV shielding. It not only provides surface protection but also reprograms oxidative stress responses by reducing ROS accumulation, restoring cuticle integrity, and enhancing tensile strength. At the molecular level, it activates antioxidant pathways while reducing apoptosis and inflammation. This multifunctional platform offers a durable and biocompatible alternative to conventional UV filters, effectively protecting hair from UV-induced oxidative damage.