research Hutchinson-Gilford Progeria Syndrome—Current Status and Prospects for Gene Therapy Treatment
Gene therapy has potential as a future treatment for Hutchinson-Gilford progeria syndrome.
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research Systemic Lupus Erythematosus: Definitions, Contexts, Conflicts, Enigmas
The document concludes that anti-dsDNA antibodies are not unique to SLE and their use as indicators is doubtful, highlighting the need for better understanding and classification of the disease.
research Breakdown of Immune Tolerance in AIRE-Deficient Rats Induces a Severe Autoimmune Polyendocrinopathy–Candidiasis–Ectodermal Dystrophy–like Autoimmune Disease
AIRE-deficient rats developed severe autoimmune disease similar to APECED, useful for testing treatments.
research Rapid Formation of Cell Aggregates and Spheroids Induced by a “Smart” Boronic Acid Copolymer
A boronic acid copolymer quickly forms cell clusters, useful for tissue and tumor modeling.
research The use of mesenchymal stromal cells in the treatment of coronavirus disease 2019
Mesenchymal stromal cells may help treat severe COVID-19, but more research is needed to confirm their effectiveness.
research Male pattern baldness and risk of incident skin cancer in a cohort of men
Men with male pattern baldness have a higher risk of certain skin cancers, especially on the scalp.
research Implication of Human Bacterial Gut Microbiota on Immune-Mediated and Autoimmune Dermatological Diseases and Their Comorbidities: A Narrative Review
An imbalance in gut bacteria is linked to skin immune diseases and may affect their outcomes and related health issues.
research ENRIQUECIMENTO AMBIENTAL ASSOCIADO A PROMOÇÃO DO BEM ESTAR PARA CAMUNDONGOS MANTIDOS EM BIOTÉRIOS
Environmental enrichment improves lab mice welfare and research outcomes.
research In vitro–in vivo assessments of apocynin-hybrid nanoparticle-based gel as an effective nanophytomedicine for treatment of rheumatoid arthritis
The gel with apocynin-loaded nanoparticles shows promise for treating rheumatoid arthritis.
research Novel Systematics of Nomenclature and Classification of Female Functional Androgenization (Including Polycystic Ovary Syndrome and Non-Classic Congenital Adrenal Hyperplasia)
A new system helps better diagnose and treat female androgenization conditions like PCOS.
research Disruption of anthrax toxin receptor 1 in pigs leads to a rare disease phenotype and protection from senecavirus A infection
Removing anthrax toxin receptor 1 in pigs prevents Senecavirus A infection and causes a rare disease similar to GAPO syndrome.
research Taming of Covid-19: potential and emerging application of mesenchymal stem cells
Mesenchymal stem cells show promise in treating COVID-19 by reducing inflammation and aiding recovery, but more research is needed.
research The role of B cell-activating factor system in autoimmune diseases: mechanisms, disease implications, and therapeutic advances
BAFF-targeted therapies can reduce autoimmune disease activity, but more research is needed for precise treatments.
research Application of Platelet-Rich Plasma as a Stem Cell Treatment - anAttempt to Clarify a Common Public Misconception
PRP is not a stem cell treatment and should not be marketed as such.
research Development of a Liquid Chromatography/Mass Spectrometry-Based Inhibition Assay for the Screening of Steroid 5-α Reductase in Human and Fish Cell Lines
A new method was created to test the effectiveness of Dihydrotestosterone (DHT) inhibitors, like finasteride and dutasteride, in human and fish cells. The results showed fish cells are more sensitive to these treatments, and dutasteride works better than finasteride in all tested cells.
research Biological effects of human placental extracts - variations in manufacturing methods and compositions
Placental extracts have antioxidant, anti-inflammatory, and immune-boosting effects, but their exact workings are unclear.
research A symphony of signals: the intricate role of lncRNAs in dermatological disorders
lncRNAs are important for understanding and treating skin diseases.
research Polysaccharide, Conjugate, and mRNA-based Vaccines are Immunogenic in Patients with Netherton Syndrome
Vaccines work well in Netherton syndrome patients, similar to healthy people.
research Caracterização e diferenciação neural in vitro de células-tronco de polpa de dente decíduo humano
Dental pulp stem cells might not reliably become neurons.
research Latent transforming growth factor beta-binding protein 1 (LTBP1): roles as a multifunctional extracellular matrix regulator in human disease. From molecular mechanisms to clinical translation prospects
LTBP1 is a key regulator in diseases and a potential target for new treatments.
research Inhibition of autophagy-lysosomal function exacerbates microglial and monocyte lipid metabolism reprograming and dysfunction after brain injury
Blocking autophagy worsens lipid buildup and dysfunction in brain cells after injury.
research Type-2 immunity associated with type-1 related skin inflammatory diseases: friend or foe?
Type-2 immunity may influence skin diseases and could be targeted for treatment.
research DOENÇA INTESTINAL INFLAMATÓRIA EM FELINOS: UMA REVISÃO DE LITERATURA
Early diagnosis and management are crucial for feline inflammatory bowel disease.
research ASPECTOS DA ESTRONGILOIDÍASE EM CÃES E O SEU IMPACTO NO ÂMBITO DA SAÚDE PÚBLICA
Dogs can transmit a parasite to humans, especially affecting those with weak immune systems, so early diagnosis and treatment are crucial.
research ABATE CLANDESTINO DE BOVINOS: RISCOS E CONSEQUÊNCIAS
Illegal cattle slaughter in Brazil poses health risks and violates laws.
research O VÍRUS DA GRIPE AVIÁRIA (H5N1): UMA REVISÃO DE LITERATURA
H5N1 avian flu poses risks to birds and humans, requiring strict biosecurity measures.
research LASERTERAPIA E SUAS APLICAÇÕES NO TRATAMENTO E REABILITAÇÃO DE PEQUENOS ANIMAIS COM OSTEOARTROSE
Laser therapy helps relieve pain and improve life quality in small animals with osteoarthritis.
research ATUALIZAÇÕES DA LEGISLAÇÃO SOBRE A RESPONSABILIDADE DO MÉDICO VETERINÁRIO NA PRESERVAÇÃO DO BEM-ESTAR ANIMAL E GARANTIA DA QUALIDADE DOS PRODUTOS DA INDÚSTRIA DE CARNES
Veterinarians are essential for ensuring animal welfare and safe meat products in Brazil.
research OCORRÊNCIA DA GIARDÍASE EM CÃES E A SUA RELEVÂNCIA PARA A SAÚDE PÚBLICA
Giardiasis in dogs poses a public health risk, requiring better diagnosis, treatment, and sanitation.
research The HEDGEHOG-GLI1 pathway is important for fibroproliferative properties in keloids and as a candidate therapeutic target
Targeting the HEDGEHOG-GLI1 pathway could help treat keloids.