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The study presents a novel tannin-modified cellulose-polypyrrole nonwoven dressing (TA/Cell@PPy) designed to accelerate wound healing by combining antimicrobial protection with electrotherapy. The dressing utilizes tannic acid for antibacterial activity against S. aureus and E. coli, and conductive polypyrrole to enhance endogenous electric fields, promoting re-epithelialization. In vivo evaluations show that TA/Cell@PPy significantly speeds up wound closure through enhanced granulation tissue, optimized collagen matrix organization, and stimulated angiogenesis. Its biomimetic nanofibrous architecture ensures biocompatibility and prevents secondary trauma during dressing changes, offering a promising solution for complex wound management by addressing infection control and tissue regeneration simultaneously.

The study presents a multifunctional hydrogel, QTMP-Gel, designed to treat oral mucositis (OM) by addressing oxidative damage and bacterial infection. The hydrogel, made from quaternary ammonium chitosan and tannic acid, adheres well to wet oral mucosa and releases drugs in response to reactive oxygen species (ROS). It contains platinum nanoparticles for ROS scavenging and minocycline hydrochloride for antibacterial and anti-inflammatory effects. In vitro tests showed excellent biocompatibility and effectiveness against E. coli and S. aureus. In a hamster model, QTMP-Gel accelerated wound healing, reduced proinflammatory cytokines, and cleared excess ROS, offering a promising approach for OM treatment.