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GlossaryLiver Function

detoxifies blood, produces bile, and synthesizes essential proteins

Liver function, also known as hepatic function, refers to the various vital processes carried out by the liver, including detoxification of harmful substances, production of bile for digestion, synthesis of proteins like albumin, and regulation of blood clotting. It is often assessed through liver function tests (LFTs), which measure levels of enzymes, proteins, and bilirubin in the blood to evaluate the liver's health and performance.

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research miR-761-hepcidin/Gpx4 pathway contribute to unexplained liver dysfunction in polycystic ovary syndrome by regulating liver iron overload and ferroptosis

16 citations , January 2023 in “Gynecological Endocrinology”

Liver damage in PCOS is linked to iron overload and cell death due to the miR-761-hepcidin/GPX4 pathway.

Metabolic Dysfunction-Associated Steatotic Liver Disease Is Associated With Androgenetic Alopecia in Adults With Stronger Effects in Women and Unhealthy Lifestyles

research Metabolic dysfunction-associated steatotic liver disease is associated with androgenetic alopecia in adults with stronger effects in women and unhealthy lifestyles

November 2025 in “Scientific Reports”

Liver disease is linked to hair loss, especially in women and those with unhealthy lifestyles.

Progressive Metabolic Dysfunction-Associated Steatotic Liver Disease from a Young Age Due to a Rare Genetic Disorder, Familial Partial Lipodystrophy: A Case Report and Review of the Literature

research Progressive Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) from a Young Age Due to a Rare Genetic Disorder, Familial Partial Lipodystrophy: A Case Report and Review of the Literature

December 2024 in “Livers”

Recognizing rare causes of MASLD is crucial for effective treatment and preventing complications.

research Liver and Kidney Dysfunction in Wistar Rats Exposed to Municipal Landfill Leachate

55 citations , August 2012 in “Resources and Environment”

Landfill leachate harms liver and kidneys in rats, posing health risks.

Long-Term Dutasteride Therapy in Men with Benign Prostatic Hyperplasia Alters Glucose and Lipid Profiles and Increases Severity of Erectile Dysfunction

research Long-term dutasteride therapy in men with benign prostatic hyperplasia alters glucose and lipid profiles and increases severity of erectile dysfunction

20 citations , June 2017 in “Hormone Molecular Biology and Clinical Investigation”

Long-term use of dutasteride for enlarged prostate may worsen blood sugar, cholesterol, and erectile dysfunction.

research Sexual dysfunction, including hypoactive sexual desire disorder: Diagnosis and treatment recommendations

1 citations , July 2015 in “Cambridge University Press eBooks”

Testosterone therapy can improve sexual function in women but long-term safety is unclear.

Finasteride, Not Tamsulosin, Increases Severity of Erectile Dysfunction and Decreases Testosterone Levels in Men With Benign Prostatic Hyperplasia

research Finasteride, not tamsulosin, increases severity of erectile dysfunction and decreases testosterone levels in men with benign prostatic hyperplasia

20 citations , June 2015 in “Hormone Molecular Biology and Clinical Investigation”

Finasteride worsens erectile dysfunction and lowers testosterone in men with enlarged prostates, unlike tamsulosin.

research Metabolic dysfunction in female mice with disruption of 5α-reductase 1

11 citations , January 2017 in “Journal of Endocrinology/Journal of endocrinology”

Female mice with disrupted 5α-reductase 1 had significant metabolic issues, including stress response problems, insulin resistance, liver fat buildup, and obesity.

Toxic Hepatitis Induced by Shou-Wu-Pian, a Chinese Herbal Preparation

research Toxic Hepatitis Induced by Show-Wu-Pian, a Chinese Herbal Preparation

37 citations , January 2010 in “Internal Medicine”

A woman's liver was damaged by taking the herbal supplement Shou-Wu-Pian, but it got better after she stopped using it.

research Negative Impact of Testosterone Deficiency and 5α-Reductase Inhibitors Therapy on Metabolic and Sexual Function in Men

31 citations , January 2017 in “Advances in Experimental Medicine and Biology”

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

research Perforating folliculitis with jaundice in an Indian male: a rare case with sclerosing cholangitis

15 citations , March 2004 in “British Journal of Dermatology”

Surgery resolved the man's skin and liver issues, and he stayed symptom-free for a year.

research EtG Quantification in Hair and Different Reference Cut-Offs in Relation to Various Pathologies: A Scoping Review

12 citations , November 2022 in “Toxics”

EtG in hair can help detect alcohol use but may be inaccurate in people with certain health conditions.

Recommendations for Endocrine Treatment of Patients with Gender Dysphoria

research Recommendations of endocrine treatment for patients with gender dysphoria

10 citations , May 2009 in “Sexual and Relationship Therapy”

The document concludes that hormone therapy is essential for treating gender dysphoria, with specific drugs and monitoring protocols recommended for safety and effectiveness.

research Influence of The Anabolic Steroid Usage on The Physical Health: A Review

1 citations , December 2024 in “Journal of Education Health and Sport”

Anabolic steroids harm the heart, liver, hormones, muscles, and mental health.

research TREATMENT OF ACNE VULGARIS, OR EVERYTHING WE SHOULD KNOW ABOUT ISOTRETINOIN

September 2024 in “Health Problems of Civilization”

Isotretinoin effectively treats severe acne but has significant side effects requiring careful monitoring.

Hepatotoxicity Secondary to a Weight Loss Drug, Orlistat: Consideration as a Differential Diagnosis

research Hepatotoxicity Secondary to A Drug to Lose Weight, "Orlistat": to take into Account as a Differential Diagnosis

February 2020 in “Scholars academic journal of pharmacy”

The weight loss drug Orlistat can cause liver damage and should be used with caution, especially in those with liver or kidney issues.

research [Reactions and side effects of ovulation inhibitors on the skin].

January 1978 in “PubMed”

Oral contraceptives can affect skin and hair, improve acne, but may cause pigmentation, dermatitis, and other conditions.

research Health Risks Associated with Long-Term Finasteride and Dutasteride Use: It’s Time to Sound the Alarm

17 citations , January 2020 in “The World Journal of Men's Health”

Long-term use of finasteride and dutasteride can cause serious health issues like diabetes and liver problems.

research Investigation, Treatment, and Monitoring of Late‐Onset Hypogonadism in Males: ISA, ISSAM, and EAU Recommendations

129 citations , February 2006 in “Andrology”

Men with low testosterone should be carefully evaluated and monitored before and during treatment.

research Potential PRP Hair Treatment Side Effects

February 2017

PRP hair treatment is generally safe but may cause minor pain, bleeding, redness, and scalp tightness, and isn't suitable for everyone.

research Lean Women with Polycystic Ovary Syndrome

1 citations , February 2018 in “InTech eBooks”

PCOS in lean women is a serious health condition with implications beyond fertility, affecting metabolism and increasing cardiovascular disease risk.

research Clinical features and presentation of polycystic ovary syndrome

April 2023 in “Elsevier eBooks”

PCOS is a hormonal disorder causing symptoms like excess hair, acne, irregular periods, and fertility issues.

research History and physical examination of polycystic ovary syndrome: Detecting too much or too little

July 2015 in “Cambridge University Press eBooks”

The document concludes that careful history and physical exams are crucial for accurately diagnosing polycystic ovary syndrome and distinguishing it from other similar conditions.

research Cutaneous Markers of Disorders Affecting Adult Horses

5 citations , December 2005 in “Clinical Techniques in Equine Practice”

Skin and hair changes in horses can indicate serious diseases, and recognizing these signs is important for treatment and management.

research Resident macrophages of the lung and liver: The guardians of our tissues

4 citations , November 2022 in “Frontiers in Immunology”

Lung and liver macrophages protect our tissues and their dysfunction can cause various diseases.

research G588(P) Transient renal and hepatic dysfunction in severe profound hypothyroidism

May 2019

Severe hypothyroidism can cause temporary liver and kidney issues, which improve with thyroxine treatment.

Case Presentation: Catastrophic Decrease in Measured Oxygen Saturation Associated with Venovenous Bypass During Liver Transplantation

research Case presentation: Catastrophic decrease in measured oxygen saturation associated with venoveno bypass during liver transplantation

July 1999 in “Liver transplantation and surgery”

Oxygen levels can drop during liver transplant if bypass pressures are too high, but other reasons should be checked first.

research Complications of liver transplantation: A perioperative perspective

2 citations , July 1999 in “Liver transplantation and surgery”

Liver transplant can lead to neurological, pulmonary, cardiovascular, and renal complications, with older patients facing higher risks.

research Careless talk costs lives: fibroblast growth factor receptor signalling and the consequences of pathway malfunction

119 citations , November 2014 in “Trends in Cell Biology”

Fibroblast growth factor receptor signaling controls cell development and repair, and its malfunction can cause disorders and cancer, but it also offers potential for targeted therapies.

research Testosterone therapy for sexual dysfunction in postmenopausal women

46 citations , January 2008 in “Climacteric”

Testosterone therapy can help improve sexual desire and function in postmenopausal women but may cause side effects and is not FDA-approved for this use.