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Fermentation of Finasteride with Ocimum sanctum L. creates new metabolite that inhibits tyrosinase.

Plant-derived amino acids can help develop new antimicrobial drugs.

Integrating biological networks improves drug repurposing and ADR prediction.

Finasteride metabolites found in pigs match human studies, making pigs a valid model for human drug research.

Researchers found two enzymes in Avicennia marina that help produce maslinic acid and corosolic acid, which have medicinal benefits.

Targeting lipid metabolism can help treat advanced, resistant cancers.

The document concludes that a new method has been developed to test anti-aging substances on human skin, showing that these substances can reduce skin aging signs.

New steroid derivatives show promise as anticancer agents, even against resistant cells.

The document concludes that scientists created various steroids with different properties, including a more effective semi-synthetic vitamin D.

Blocking both main energy pathways can stop hair follicle stem cell-induced skin cancer growth.

Patients with acne and insulin resistance have different blood metabolites compared to those with only acne, which could help in diagnosis and treatment.

Mitotane changes steroid breakdown, affecting cortisol availability.

Mutant stem cells adapt their metabolism differently to outcompete normal cells in the skin.

New indole-based compounds, particularly cemtirestat, show promise as dual-function drugs for diabetic complications.

Reconstructed skin models are useful for studying how skin processes certain chemicals.

We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.

Existing drugs are being repurposed to treat cardiometabolic disorders, which is safer, faster, and cheaper than developing new drugs.

PPAR-γ signaling improves mitochondrial function in hair follicles, potentially affecting hair growth and aging.

Manipulating 5α-reductase type 2 can affect liver fat production and glucocorticoid effects.

Eight blood metabolites are linked to causing allergic conjunctivitis, offering new ways to predict and treat it.

Human hair follicles have a unique metabolism that changes between growth stages and may contribute to baldness.

A fungal enzyme was used to make compounds more soluble, aiding drug discovery and crop protection.

Certain plant compounds can help treat diabetes.

5α-reductases increase epitestosterone's effect on androgen receptors.

A new, efficient method creates sulfinimidate esters from sulfenamides and alcohols without metals.

Cis-UCA can form new compounds without enzymes, and sulphide donors reduce its UVB-induced toxicity in skin cells.

Changing the 6-position on benzopyran molecules affects insulin release, with some compounds showing strong inhibitory effects.