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GlossaryRandomized Controlled Trials

scientific studies comparing treatments by randomly assigning participants

Randomized Controlled Trials (RCTs) are scientific studies designed to test the effectiveness of medical treatments or interventions by randomly assigning participants to either a treatment group or a control group. This randomization helps eliminate bias, ensuring that any differences observed between the groups can be attributed to the treatment itself rather than other factors. RCTs are considered the gold standard in clinical research for establishing causality and assessing the efficacy and safety of new therapies.

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research A randomized, placebo-controlled trial of 1% topical minoxidil solution in the treatment of androgenetic alopecia in Japanese women.

10 citations , May 2007 in “PubMed”

1% topical minoxidil solution significantly improved hair growth in Japanese women with androgenetic alopecia, with no major side effects.

Randomized Controlled Trial on a PRP-Like Cosmetic with Biomimetic Peptides for the Treatment of Alopecia Areata

research Randomized controlled trial on a PRP-like cosmetic, biomimetic peptides based, for the treatment of alopecia areata

8 citations , December 2018 in “Journal of Dermatological Treatment”

The PRP-like cosmetic with biomimetic peptides is potentially effective and safe for treating alopecia areata.

Response to Baricitinib in the Treatment of Patients with Early and Late Onset Alopecia Areata in the Phase 2 Portion of BRAVE-AA1 Randomized Controlled Trial

research 27604 Response to baricitinib in the treatment of patients with early and late onset alopecia areata in the phase 2 portion of BRAVE-AA1 randomized controlled trial

1 citations , August 2021 in “Journal of The American Academy of Dermatology”

Baricitinib was effective in treating both early and late onset alopecia areata.

Scalp Acupoint Catgut Embedding Combined With Topical 5% Minoxidil Tincture to Improve Male Androgenetic Alopecia: Protocol for a Randomized Controlled Trial

research Scalp acupoint catgut embedding combined with topical 5% minoxidil tincture to improve male androgenetic alopecia: protocol for a randomised controlled trial

August 2025 in “BMJ Open”

Combining scalp acupoint catgut embedding with 5% minoxidil may help treat male pattern baldness.

Therapeutic Effects of Topical Cetirizine in the Treatment of Female Pattern Hair Loss: A Randomized Controlled Noninferiority Trial

research Therapeutic effects of topical cetirizine in the treatment of female pattern hair loss: a randomized controlled noninferiority trial

August 2023 in “Expert Review of Clinical Pharmacology”

Cetirizine lotion can effectively treat female pattern hair loss.

Photobiomodulation Therapy for the Management of Chemotherapy-Induced Alopecia: Preliminary Results of a Randomized, Controlled Trial

research 213P Photobiomodulation therapy for the management of chemotherapy-induced alopecia: Preliminary results of a randomized, controlled trial

May 2022 in “Annals of Oncology”

Photobiomodulation therapy may speed up hair regrowth after chemotherapy in the short term.

research Randomized controlled trial to compare the efficacy of oral minoxidil 1.25 mg versus 2.5 mg versus topical 5% minoxidil in androgenetic alopecia

January 2026 in “Dermatologica Sinica”

Both oral and topical minoxidil effectively regrow hair in men with similar results.

Randomized Controlled Trial on the Efficacy and Safety of the Combination Therapy of Topical 0.1% Finasteride and 5% Minoxidil in Male Androgenetic Alopecia

research Randomized controlled trial on the efficacy and safety of the combination therapy of topical 0.1% finasteride − 5% Minoxidil in male androgenetic alopecia

April 2025 in “Archives of Dermatological Research”

The combination of finasteride and minoxidil is as safe and effective as minoxidil alone for improving hair growth in men.

Randomized Controlled Trial to Evaluate the Efficacy of Combination Therapy with Diphenylcyclopropenone and Platelet-Rich Plasma in Alopecia Areata

research Randomized Controlled Trial Study to Evaluate the Efficacy of Combination Therapy with Diphenylcyclopropenone and Platelet-Rich Plasmain Alopecia Areaata

January 2025 in “International Journal of Trichology”

Combining DPCP with PRP doesn't improve hair regrowth in alopecia areata.

Comparative Efficacy and Safety of Low-Level Laser Therapy and Topical Minoxidil Combination vs. Topical Minoxidil Monotherapy in Androgenetic Alopecia Management: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

research Comparative efficacy and safety of low-level laser therapy and topical Minoxidil combination vs. topical Minoxidil monotherapy in androgenetic alopecia management: a systematic review and meta-analysis of randomized controlled trials

August 2025 in “Lasers in Medical Science”

Combining laser therapy with minoxidil improves hair growth and satisfaction without extra side effects.

research Efficacy of polyphenolic compounds for hair regeneration: a systematic review and meta-analysis of randomized controlled trials

April 2026 in “Figshare”

Polyphenolic compounds may help hair growth but aren't better than minoxidil.

research Efficacy of polyphenolic compounds for hair regeneration: a systematic review and meta-analysis of randomized controlled trials

April 2026 in “Figshare”

Polyphenolic compounds may help hair growth but need more research.

research Efficacy of polyphenolic compounds for hair regeneration: a systematic review and meta-analysis of randomized controlled trials.

April 2026 in “PubMed”

Polyphenolic compounds may help improve hair growth in non-scarring alopecia.

research P06 Evaluating the efficacy and safety of combined microneedling therapy vs. topical minoxidil in androgenetic alopecia: a systematic review and meta-analysis of randomized controlled trials

January 2026 in “British Journal of Dermatology”

Combined microneedling with minoxidil improves hair growth more than minoxidil alone for hair loss.

Combined Minoxidil and Platelet-Rich Plasma Compared With Monotherapy in Androgenetic Alopecia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

research 64082 Combined Minoxidil and Platelet-Rich Plasma Compared With Monotherapy in Androgenetic Alopecia: A Systematic Review and Meta-analysis of Randomized Controlled Trials

September 2025 in “Journal of the American Academy of Dermatology”

Combining minoxidil and PRP is more effective for hair growth than using either alone.

research Comparing the Efficacy of Mesotherapy to Topical Minoxidil in the Treatment of Female Pattern Hair Loss Using Ultrasound Biomicroscopy: A Randomized Controlled Trial.

March 2019 in “PubMed”

Mesotherapy is more effective and preferred for female hair loss than topical minoxidil.

research A randomized, placebo-controlled trial of 5% and 2% topical minoxidil solutions in the treatment of female pattern hair loss

219 citations , March 2004 in “Journal of The American Academy of Dermatology”

5% and 2% minoxidil solutions effectively promote hair growth and reduce hair loss, with 5% being slightly more effective but having more side effects.

research Intradermal injections with 0.5% minoxidil for the treatment of female androgenetic alopecia: A randomized, placebo‐controlled trial

7 citations , December 2020 in “Dermatologic Therapy”

Injections with 0.5% minoxidil effectively treat female hair loss, increasing hair density and thickness.

Hair Growth Effect of Traditional Chinese Medicine BeauTop on Androgenetic Alopecia Patients: A Randomized Double-Blind Placebo-Controlled Clinical Trial

research Hair growth effect of traditional Chinese medicine BeauTop on androgenetic alopecia patients: A randomized double-blind placebo-controlled clinical trial

5 citations , November 2016 in “Experimental and Therapeutic Medicine”

BeauTop improves hair growth in androgenetic alopecia patients.

research Evaluation of platelet-rich plasma as a treatment for androgenetic alopecia: A randomized controlled trial

33 citations , July 2020 in “Journal of The American Academy of Dermatology”

PRP treatment improves hair density and thickness for alopecia, but needs more research.

research The effect of platelet-rich plasma on female androgenetic alopecia: A randomized controlled trial

18 citations , July 2020 in “Journal of The American Academy of Dermatology”

PRP injections improve hair density and thickness in women with hair loss.

research A randomized controlled trial comparing total glucosides of paeony capsule and compound glycyrrhizin tablet for alopecia areata

18 citations , August 2012 in “Chinese journal of integrative medicine/Chinese Journal of Integrative Medicine”

Both treatments for alopecia areata are equally effective and safe.

research Comparing the effects of zinc sulfate, calcium pantothenate, their combination and minoxidil solution regimens on controlling hair loss in women: A randomized controlled trial

11 citations , April 2017 in “Journal of research in pharmacy practice”

The combination of zinc sulfate and calcium pantothenate effectively controls early-stage hair loss.

research The impact of a lifestyle promotion program on anthropometric and clinical manifestations in adolescents with polycystic ovarian syndrome: a randomized controlled trial

6 citations , December 2024 in “BMC Women s Health”

Lifestyle changes improve weight, waist size, menstrual regularity, and acne in teens with PCOS.

research Unveiling Therapeutic Potential of Yoga Mitigating Oxidative Stress and Mitochondrial Dysfunction in PCOS: A Randomized Controlled Trial

4 citations , January 2025 in “International Journal of Yoga”

Yoga helps manage PCOS symptoms and improves overall health.

research Randomized Placebo-Controlled Clinical Trial of Dutasteride for Reducing Heavy Drinking in Men

2 citations , April 2024 in “Journal of Clinical Psychopharmacology”

Dutasteride helps reduce heavy drinking, especially for those who drink to cope.

research Platelet-Rich Plasma Injection into the Colorectal Anastomosis Reduces the Anastomotic Leakage Incidence: A Randomized Controlled Trial

1 citations , January 2025 in “OALib”

Injecting Platelet-Rich Plasma reduces leakage risk in colorectal surgery.

Comparative Study of the Efficacy and Safety of Topical Minoxidil 2% Versus Topical Bimatoprost 0.01% Versus Topical Bimatoprost 0.03% in Treatment of Eyebrow Hypotrichosis: A Randomized Controlled Trial

research Comparative study of the efficacy and safety of topical minoxidil 2% versus topical bimatoprost 0.01% versus topical bimatoprost 0.03% in treatment of eyebrow hypotrichosis: a randomized controlled trial

1 citations , July 2023 in “Archives of dermatological research”

Bimatoprost 0.03% is as effective as minoxidil 2% for eyebrow growth.

research A Randomized Controlled Clinical Trial Protocol of Umbilical Cord Mesenchymal Stem Cell‐Derived Small Extracellular Vesicles for the Treatment of Androgenetic Alopecia in Young Males

January 2026 in “The FASEB Journal”

The trial aims to test a new treatment for hair loss in young men using stem cell-derived vesicles.

research Efficacy and Safety of Mesotherapy With 0.5% Minoxidil Versus Topical 2% Minoxidil for Female Androgenetic Alopecia: A Randomized Controlled Trial

January 2026 in “Dermatologic Therapy”

0.5% minoxidil mesotherapy is more effective and safe for hair growth in women with androgenetic alopecia than topical 2% minoxidil.