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This study examined serum levels of phoenixin-14 (PNX-14) and phoenixin-20 (PNX-20) in 90 women with polycystic ovary syndrome (PCOS) compared to 60 healthy controls, finding that both isoforms were significantly elevated in PCOS patients. These isoforms positively correlated with anti-Müllerian hormone (AMH), insulin, and luteinizing hormone (LH), and negatively with sex hormone-binding globulin (SHBG) and high-density lipoprotein (HDL) cholesterol. The study demonstrated moderate diagnostic utility for PNX isoforms, with AUC values of 0.834 for PNX-14 and 0.819 for PNX-20, suggesting their potential role in multi-marker assessment frameworks for PCOS. However, the cross-sectional design limits causal conclusions, necessitating further research to validate these associations.

The paper proposes an integrative framework for patient-centered care in Aesthetic Medicine and Aesthetic Health Psychology, emphasizing the alignment of physical changes with psychological well-being and quality of life. It introduces models like the Aesthetic–Biopsychosocial Model to guide care, focusing on aesthetic satisfaction, self-congruence, and psychosocial reintegration. The framework highlights the importance of psychological screening, managing expectations, and addressing body dysmorphic disorder. It underscores the need for comprehensive, multidisciplinary approaches that consider psychological, social, and cultural factors, alongside technical proficiency, to ensure ethical and sustainable practices. The document also emphasizes the role of primary care providers in integrating aesthetic concerns into preventive health assessments and calls for future research to validate outcome measures across diverse populations.