January 2023 in “Annals of Dermatology” Patients with a specific genetic variant have more severe alopecia areata and higher recurrence rates.
15 citations
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May 2014 in “Journal of Biological Chemistry” A chimeric keratin partially improved skin structure in mice lacking keratin 5, but didn't fully restore normal skin.
1 citations
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April 2024 in “Russian Journal of Clinical Dermatology and Venereology” Atopic diseases worsen alopecia areata, leading to earlier onset and more severe forms.
December 2025 in “Egyptian Reviews for Medical and Health Sciences .” More lesions mean more severe alopecia areata.
1 citations
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March 2012 in “Revue neurologique” Proper diet management is crucial for preventing severe symptoms in phenylketonuria.
35 citations
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November 2022 in “The Journal of Dermatology” Alopecia areata is becoming more common in Japan, with a need for better treatments, especially for severe and pediatric cases.
April 2026 in “Clinical and Translational Science” Tofacitinib effectively treats severe alopecia areata, improving hair regrowth and patient satisfaction.
October 2024 in “Canadian Journal of Health Technologies” Olumiant should be covered for severe alopecia areata if certain conditions are met.
Baricitinib helps keep hair, eyebrows, and eyelashes regrown for 3 years in most people with severe hair loss.
November 2023 in “Dermatologica sinica/Zhōnghuá pífūkē yīxué zázhì” Upadacitinib helped regrow hair in a severe alopecia areata patient but stopping treatment caused hair loss to return.
January 2016 in “Indian Journal of Paediatric Dermatology” The treatment is effective and safe for severe alopecia areata in children, but not for total or universal hair loss.
73 citations
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June 2010 in “PLoS Genetics” A gene mutation in mice causes hair loss, weak bones, and protein buildup, showing how protein processing issues can lead to diseases.
2 citations
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March 2024 in “Meditsinskiy sovet = Medical Council” JAK inhibitors effectively treat severe atopic dermatitis and alopecia areata.
August 2022 in “Dermatology Online Journal” Oral and topical tofacitinib can effectively treat severe hair loss with minimal side effects.
July 2022 in “Al-Mağallaẗ al-ʻirāqiyyaẗ li-l-ṣaydalaẗ” Lower zinc levels are linked to more severe hair loss in alopecia areata.
March 2014 in “Journal of The American Academy of Dermatology” Azathioprine may be an effective treatment for severe hair loss.
6 citations
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March 2024 in “SKIN The Journal of Cutaneous Medicine” Ritlecitinib is effective for long-term treatment of severe alopecia areata.
1 citations
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January 2020 in “Surgical & Cosmetic Dermatology” Combining oral minoxidil with JAK inhibitors helps regrow hair in severe alopecia areata cases.
November 2024 in “SKIN The Journal of Cutaneous Medicine” Ritlecitinib effectively promotes hair regrowth in severe and very severe alopecia areata.
October 2024 in “International Journal of Research in Dermatology” Tofacitinib is a promising and safe treatment for moderate to severe alopecia areata.
April 2024 in “Research Square” IBD patients treated with TNF antagonists may develop autoimmune alopecia areata, with severe cases less likely to improve.
6 citations
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March 2019 in “JAAD case reports” A new mix of anthralin and calcipotriene might help treat severe hair loss.
August 2025 in “Figshare” Alopecia areata patients, especially with severe forms, have a higher risk of cardiovascular disease.
3 citations
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January 2022 in “Russian Medical Inquiry” Atopic dermatitis may trigger alopecia areata, and early treatment can help prevent severe cases.
1 citations
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November 2023 in “Skin Appendage Disorders” 308 nm excimer lamp therapy is effective for alopecia areata but less so for severe cases.
1 citations
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March 2023 in “Journal of Drugs in Dermatology” Dupilumab may help regrow hair in people with severe alopecia.
December 2025 in “Chinese Medical Journal” Experts recommend starting systemic treatment for alopecia areata when the condition is severe or causes significant distress.
August 2024 in “Journal of Vaccines Immunology and Immunopathology” A COVID-19 vaccine may trigger severe hair loss in rare cases.
January 2022 in “Clinical Cases in Dermatology” An 11-year-old girl with severe hair loss was successfully treated with a new combination therapy.
17 citations
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January 2019 in “Dermatologic Therapy” Tofacitinib is effective and safe for long-term treatment of severe alopecia areata, with many patients achieving complete hair regrowth.