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Scientists have improved 3D models of human skin for research and medical uses, but still face challenges in perfectly replicating real skin.

Solid lipid nanoparticles are promising for safe and effective drug delivery but need more research for clinical use.

Engineered extracellular vesicles could improve CRISPR/Cas delivery, making gene editing safer and more effective.

Smart nano-PROTACs improve cancer treatment by targeting proteins more precisely and reducing side effects.

Paclitaxel is an effective cancer drug with side effects and potential new uses beyond cancer.

Drug repurposing speeds up development, cuts costs, and uses known safe drugs, but faces challenges like regulations and patents.

53BP1 focus analysis in hair cells can help estimate radiation doses.

Intestinal intraepithelial lymphocytes are crucial for gut immunity and maintaining the mucosal barrier.

Nanomaterials show promise in improving wound healing but require more research on their potential toxicity.

Vitamin B5 and coenzyme A may help regulate the immune system and could improve treatments for chronic diseases and cancer.

Microneedles are promising for disease monitoring and drug delivery due to their minimal invasiveness and versatility.

OX40-targeted therapies may help treat skin diseases by reducing inflammation and balancing immune responses.

Low-dose radiation affects hair stem cell function and survival by changing their genetic material's structure.

Nanozymes have potential for medical use but face challenges like safety and regulation.

Microneedles improve delivery of plant-based compounds through the skin, aiding treatments for hair loss, cancer, and wounds.

Engineered extracellular vesicles can improve tissue repair and regeneration.

Ustekinumab successfully treated a man's resistant skin condition when other treatments failed.

Immune checkpoint inhibitors can cause scalp inflammation and hair follicle issues.

Cancer patients treated with immune checkpoint inhibitors may develop alopecia, but some hair regrowth is possible with treatment.

Checkpoint inhibitor therapy can cause skin issues, from mild rashes to severe reactions.

A cancer patient's hair became permanently curly after treatment with nivolumab.

Sintilimab treatment caused hair loss but led to complete tumor remission.

Tislelizumab can cause cutaneous lupus erythematosus.

Pembrolizumab can cause serious liver issues, requiring close monitoring and early treatment.

Immunotherapy for cancer caused a patient to develop a condition affecting hormone production, requiring ongoing hormone replacement therapy.

Anti-PD-L1 immunotherapy can cause hair loss and unexpected hair color change, but treatment can restore hair growth and color.

Nail changes from immunotherapy can be managed without stopping cancer treatment.

INTASYL is a promising, adaptable RNAi technology for treating skin cancers.

HPV infection is linked to better survival in advanced anal cancer, higher radiation doses improve survival, especially in HPV-negative patients, and prostaglandin E₂ pretreatment can protect mouse hair follicles from radiation damage.

EGFR and MEK inhibitors reduce PD-L1 in hair follicles, possibly causing inflammation.